Reconstructive Methodology in the Synthesis of 2-Aminopurine

Abstract

A fundamentally new synthetic approach to the synthesis of 2-aminopurine has been developed. It consists in the combination of the creation of a condensed polyazotic heterocyclic tetrazolopyrimidine structure, its transformation into triaminopyrimidine, and its subsequent cyclization into 2-aminopurine. The structure of the obtained compounds was established based on spectral characteristics, and the structure of the intermediate compound 5 was established directly by X-ray diffraction analysis.

Keywords

• tetrazololopyrimidines
• purines
• reduction
• nitro group transformations
• condensation
• reconstructive methodology