Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon

Abstract

There is heterogeneity in the response to self-ligands within the naïve CD8+ T cell pool and the consequences of this are unclear. Here the authors show subsets of naïve CD8+ T cells which differ in expression of Ly6C and CD5 and response to viral infection through regulation by type I IFN signalling.