Supramammillary glutamate neurons are a key node of the arousal system

Nigel P. Pedersen; Loris Ferrari; Anne Venner; Joshua L. Wang; Stephen B. G. Abbott; Nina Vujovic; Elda Arrigoni; Clifford B. Saper; Patrick M. Fuller

doi:10.1038/s41467-017-01004-6

Nature Communications (Nov 2017)

Supramammillary glutamate neurons are a key node of the arousal system

Nigel P. Pedersen,
Loris Ferrari,
Anne Venner,
Joshua L. Wang,
Stephen B. G. Abbott,
Nina Vujovic,
Elda Arrigoni,
Clifford B. Saper,
Patrick M. Fuller

Affiliations

Nigel P. Pedersen: Department of Neurology and Epilepsy Service, Emory University
Loris Ferrari: Department of Neurology, Beth Israel Deaconess Medical Center
Anne Venner: Department of Neurology, Beth Israel Deaconess Medical Center
Joshua L. Wang: Department of Neurology, Beth Israel Deaconess Medical Center
Stephen B. G. Abbott: Department of Neurology, Beth Israel Deaconess Medical Center
Nina Vujovic: Division of Sleep Medicine, Harvard Medical School
Elda Arrigoni: Department of Neurology, Beth Israel Deaconess Medical Center
Clifford B. Saper: Department of Neurology, Beth Israel Deaconess Medical Center
Patrick M. Fuller: Department of Neurology, Beth Israel Deaconess Medical Center

DOI: https://doi.org/10.1038/s41467-017-01004-6
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

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Supramammillary nucleus (SuM) neurons have been studied in the context of REM sleep but their possible role in mediating wakefulness is not known. Here the authors elucidate the distinct functional contributions of three subpopulations in the SuM on electrographical and behavioral arousal in mice using genetically targeted approaches.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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