New Trisulfated Steroids from the Vietnamese Marine Sponge <i>Halichondria vansoesti</i> and Their PSA Expression and Glucose Uptake Inhibitory Activities

Kseniya  M. Tabakmakher; Tatyana  N. Makarieva; Vladimir  A. Denisenko; Roman  S. Popov; Pavel  S. Dmitrenok; Sergey  A. Dyshlovoy; Boris  B. Grebnev; Carsten Bokemeyer; Gunhild von Amsberg; Nguyen  X. Cuong

doi:10.3390/md17080445

Marine Drugs (Jul 2019)

New Trisulfated Steroids from the Vietnamese Marine Sponge <i>Halichondria vansoesti</i> and Their PSA Expression and Glucose Uptake Inhibitory Activities

Kseniya M. Tabakmakher,
Tatyana N. Makarieva,
Vladimir A. Denisenko,
Roman S. Popov,
Pavel S. Dmitrenok,
Sergey A. Dyshlovoy,
Boris B. Grebnev,
Carsten Bokemeyer,
Gunhild von Amsberg,
Nguyen X. Cuong

Affiliations

Kseniya M. Tabakmakher: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
Tatyana N. Makarieva: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
Vladimir A. Denisenko: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
Roman S. Popov: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
Pavel S. Dmitrenok: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
Sergey A. Dyshlovoy: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
Boris B. Grebnev: G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
Carsten Bokemeyer: Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
Gunhild von Amsberg: Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany
Nguyen X. Cuong: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi 100000, Vietnam

DOI: https://doi.org/10.3390/md17080445
Journal volume & issue: Vol. 17, no. 8
p. 445

Abstract

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Seven new unusual polysulfated steroids—topsentiasterol sulfate G (1), topsentiasterol sulfate I (2), topsentiasterol sulfate H (3), bromotopsentiasterol sulfate D (4), dichlorotopsentiasterol sulfate D (8), bromochlorotopsentiasterol sulfate D (9), and 4β-hydroxyhalistanol sulfate C (10), as well as three previously described—topsentiasterol sulfate D (7), chlorotopsentiasterol sulfate D (5) and iodotopsentiasterol sulfate D (6) have been isolated from the marine sponge Halichondria vansoesti. Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

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