Viruses (Apr 2018)
Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum β-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo
- Elene Kakabadze,
- Khatuna Makalatia,
- Nino Grdzelishvili,
- Nata Bakuradze,
- Marina Goderdzishvili,
- Ia Kusradze,
- Marie-France Phoba,
- Octavie Lunguya,
- Cédric Lood,
- Rob Lavigne,
- Jan Jacobs,
- Stijn Deborggraeve,
- Tessa De Block,
- Sandra Van Puyvelde,
- David Lee,
- Aidan Coffey,
- Anahit Sedrakyan,
- Patrick Soentjens,
- Daniel De Vos,
- Jean-Paul Pirnay,
- Nina Chanishvili
Affiliations
- Elene Kakabadze
- Eliava Institute of Bacteriophage, Microbiology & Virology and Tbilisi State University, Gotua Street 3, Tbilisi 0160, Georgia
- Khatuna Makalatia
- Eliava Institute of Bacteriophage, Microbiology & Virology and Tbilisi State University, Gotua Street 3, Tbilisi 0160, Georgia
- Nino Grdzelishvili
- Eliava Institute of Bacteriophage, Microbiology & Virology and Tbilisi State University, Gotua Street 3, Tbilisi 0160, Georgia
- Nata Bakuradze
- Eliava Institute of Bacteriophage, Microbiology & Virology and Tbilisi State University, Gotua Street 3, Tbilisi 0160, Georgia
- Marina Goderdzishvili
- Eliava Institute of Bacteriophage, Microbiology & Virology and Tbilisi State University, Gotua Street 3, Tbilisi 0160, Georgia
- Ia Kusradze
- Eliava Institute of Bacteriophage, Microbiology & Virology and Tbilisi State University, Gotua Street 3, Tbilisi 0160, Georgia
- Marie-France Phoba
- National Institute for Biomedical Research, University Teaching Hospital of Kinshasa, Kinshasa, Democratic Republic of the Congo
- Octavie Lunguya
- National Institute for Biomedical Research, University Teaching Hospital of Kinshasa, Kinshasa, Democratic Republic of the Congo
- Cédric Lood
- KU Leuven, Laboratory for Gene Technology, B-3000 Leuven, Belgium
- Rob Lavigne
- KU Leuven, Laboratory for Gene Technology, B-3000 Leuven, Belgium
- Jan Jacobs
- Department of Clinical Sciences, Institute of Tropical Medicine, B-2000 Antwerpen, Belgium
- Stijn Deborggraeve
- Department of Biomedical Sciences, Institute of Tropical Medicine, B-2000 Antwerpen, Belgium
- Tessa De Block
- Department of Biomedical Sciences, Institute of Tropical Medicine, B-2000 Antwerpen, Belgium
- Sandra Van Puyvelde
- Department of Biomedical Sciences, Institute of Tropical Medicine, B-2000 Antwerpen, Belgium
- David Lee
- Department of Biological Sciences, Cork Institute of Technology, Cork T12 P928, Ireland
- Aidan Coffey
- Department of Biological Sciences, Cork Institute of Technology, Cork T12 P928, Ireland
- Anahit Sedrakyan
- Institute of Molecular Biology, 0014 Yerevan, Armenia
- Patrick Soentjens
- Department of Clinical Sciences, Institute of Tropical Medicine, B-2000 Antwerpen, Belgium
- Daniel De Vos
- Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, B-1120 Brussels, Belgium
- Jean-Paul Pirnay
- Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, B-1120 Brussels, Belgium
- Nina Chanishvili
- Eliava Institute of Bacteriophage, Microbiology & Virology and Tbilisi State University, Gotua Street 3, Tbilisi 0160, Georgia
- DOI
- https://doi.org/10.3390/v10040172
- Journal volume & issue
-
Vol. 10,
no. 4
p. 172
Abstract
Recently, a Salmonella Typhi isolate producing CTX-M-15 extended spectrum β-lactamase (ESBL) and with decreased ciprofloxacin susceptibility was isolated in the Democratic Republic of the Congo. We have selected bacteriophages that show strong lytic activity against this isolate and have potential for phage-based treatment of S. Typhi, and Salmonella in general.
Keywords
- typhoid fever
- Salmonella Typhi
- extended-spectrum beta lactamases (ESBL)
- Democratic Republic of the Congo
- bacteriophages
