Nature Communications (Jul 2019)
Quantitative characterization of 3D bioprinted structural elements under cell generated forces
- Cameron D. Morley,
- S. Tori Ellison,
- Tapomoy Bhattacharjee,
- Christopher S. O’Bryan,
- Yifan Zhang,
- Kourtney F. Smith,
- Christopher P. Kabb,
- Mathew Sebastian,
- Ginger L. Moore,
- Kyle D. Schulze,
- Sean Niemi,
- W. Gregory Sawyer,
- David D. Tran,
- Duane A. Mitchell,
- Brent S. Sumerlin,
- Catherine T. Flores,
- Thomas E. Angelini
Affiliations
- Cameron D. Morley
- University of Florida, Herbert Wertheim College of Engineering, Department of Mechanical and Aerospace Engineering
- S. Tori Ellison
- University of Florida, Herbert Wertheim College of Engineering, Department of Materials Science and Engineering
- Tapomoy Bhattacharjee
- Princeton University, Department of Chemical and Biological Engineering
- Christopher S. O’Bryan
- University of Florida, Herbert Wertheim College of Engineering, Department of Mechanical and Aerospace Engineering
- Yifan Zhang
- University of Florida, Herbert Wertheim College of Engineering, Department of Mechanical and Aerospace Engineering
- Kourtney F. Smith
- University of Florida, Herbert Wertheim College of Engineering, Department of Materials Science and Engineering
- Christopher P. Kabb
- University of Florida, George and Josephine Butler Polymer Research Laboratory, Center for Macromolecular Science and Engineering, Department of Chemistry
- Mathew Sebastian
- Division of Neuro-Oncology, Preston A. Wells, Jr. Center for Brain Tumor Therapy, Lillian S. Wells Department of Neurosurgery, University of Florida
- Ginger L. Moore
- University of Florida, Brain Tumor Immunotherapy Program, Preston A. Wells Jr. Center for Brain Tumor Therapy, Lillian S. Wells Department of Neurosurgery
- Kyle D. Schulze
- Auburn University, Department of Mechanical Engineering
- Sean Niemi
- University of Florida, Herbert Wertheim College of Engineering, Department of Mechanical and Aerospace Engineering
- W. Gregory Sawyer
- University of Florida, Herbert Wertheim College of Engineering, Department of Mechanical and Aerospace Engineering
- David D. Tran
- Division of Neuro-Oncology, Preston A. Wells, Jr. Center for Brain Tumor Therapy, Lillian S. Wells Department of Neurosurgery, University of Florida
- Duane A. Mitchell
- University of Florida, Brain Tumor Immunotherapy Program, Preston A. Wells Jr. Center for Brain Tumor Therapy, Lillian S. Wells Department of Neurosurgery
- Brent S. Sumerlin
- University of Florida, George and Josephine Butler Polymer Research Laboratory, Center for Macromolecular Science and Engineering, Department of Chemistry
- Catherine T. Flores
- University of Florida, Brain Tumor Immunotherapy Program, Preston A. Wells Jr. Center for Brain Tumor Therapy, Lillian S. Wells Department of Neurosurgery
- Thomas E. Angelini
- University of Florida, Herbert Wertheim College of Engineering, Department of Mechanical and Aerospace Engineering
- DOI
- https://doi.org/10.1038/s41467-019-10919-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 9
Abstract
Advances in biofabrication technology enable 3D printed constructs to resemble real tissues, but it remains unclear how cell-generated forces deform these constructs. Here the authors investigate mechanical behaviours of 3D printed “microbeams” made from mixtures of living cells and extracellular matrix.
