Applications of in vivo SPME based on mass spectrometry for environmental pollutants analysis and non-target metabolomics: A review

Xinying Gong; Shu Lin; Xiaoyu Huang; Sheng Peng; Minhui Shen; Sai Ouyang; Juan Zheng; Jianqiao Xu; Gangfeng Ouyang

Green Analytical Chemistry (Apr 2022)

Applications of in vivo SPME based on mass spectrometry for environmental pollutants analysis and non-target metabolomics: A review

Xinying Gong,
Shu Lin,
Xiaoyu Huang,
Sheng Peng,
Minhui Shen,
Sai Ouyang,
Juan Zheng,
Jianqiao Xu,
Gangfeng Ouyang

Affiliations

Xinying Gong: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/KLGHEI of Environment and Energy Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China
Shu Lin: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/KLGHEI of Environment and Energy Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China
Xiaoyu Huang: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/KLGHEI of Environment and Energy Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China
Sheng Peng: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/KLGHEI of Environment and Energy Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China
Minhui Shen: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/KLGHEI of Environment and Energy Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China
Sai Ouyang: Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials, School of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414006, Hunan, China
Juan Zheng: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/KLGHEI of Environment and Energy Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China
Jianqiao Xu: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/KLGHEI of Environment and Energy Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China
Gangfeng Ouyang: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/KLGHEI of Environment and Energy Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China; Corresponding author.

Journal volume & issue: Vol. 1
p. 100004

Abstract

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In vivo analysis of environmental organic pollutants and endogenous metabolites has great impacts on understanding their environmental behavior and exposure risks. This calls for the development of convenient and reliable analytical methods with either high specificity or wide coverage of target compounds in complex matrixes. Different from traditional solvent extraction, solid-phase microextraction (SPME) has emerged as an integrated sample preparation technique by combining sampling, extraction, and cleanup into one step, which exerts great potential on in vivo sampling due to its high sensitivity and low invasiveness. In this view, the design principles of SPME fibers for in vivo sampling, novel SPME fibers, and devices over recent years are summarized for the guidance of SPME fiber design. The applications of in vivo SPME on monitoring uptake, translocation, and degradation of environmental organic pollutants in organisms, as well as non-target metabolomics in environmental toxicology and clinical analysis based on mass spectrometry, are described. SPME fiber directly coupled with mass spectrometry for in vivo analysis has been introduced. The practical limitations and prospects of further research are also discussed. We conceive that in vivo SPME will promote the development of environmental analysis and toxicity assessment in a high-efficiency and high-throughput manner.

Published in Green Analytical Chemistry

ISSN: 2772-5774 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry: Analytical chemistry
Website: https://www.sciencedirect.com/journal/green-analytical-chemistry

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