NLR, MPV and RDW as Biomarkers in Operated and Non-operated Patients with Colorectal Adenocarcinoma

Abstract

Objective:There is a need for inexpensive, reliable and readily available biomarkers in the early diagnosis and prediction of mortality, morbidity and treatment response in colorectal cancer (CRC). In our study, it was aimed to compare mean platelet volume (MPV), red cell distribution width (RDW) and neutrophil-lymphocyte ratio (NLR) measurements in operated and non-operated patients with the diagnosis of CRC.Method:In our study, we retrospectively reviewed 52 patients (including 26 operated patients and 26 non-operated patients) diagnosed as CRC with colonoscopic biopsy at endoscopy unit of gastroenterology department between 2016 and 2019. We extracted and compared demographic, colonoscopy, clinical, laboratory and surgical data in both groups.Results:In our study, the mean age (60.04 years and 64.19 years, respectively) and gender distribution (female: male, 12: 14 and 11: 15, respectively) were comparable in operated and non-operated patients with CRC. MPV, RDW and NLR measurements were found to be significantly lower in patients who underwent surgery (operated) when compared to non-operated patients (p<0.001, p=0.026 and p<0.001, respectively).Conclusion:There is strong evidence suggesting that inflammation plays a role in the pathogenesis of many disorders including malignancy. In our study, it was found that inflammatory markers, namely MPV, RDW and NLR values, were lower after surgery which removed tumor; thus, inflammation. These biomarkers can be suggestive for early diagnosis in CRC as well as response to surgical treatment.

Keywords

• nlr (neutrophil-lymphocyte ratio)
• mpv (mean platelet volume)
• rdw (red cell distribution width)
• operation
• colorectal adenocarcinoma