Nature Communications (Aug 2019)
Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes
- Amar Singh,
- Sabarinathan Ramachandran,
- Melanie L. Graham,
- Saeed Daneshmandi,
- David Heller,
- Wilma Lucia Suarez-Pinzon,
- Appakalai N. Balamurugan,
- Jeffrey D. Ansite,
- Joshua J. Wilhelm,
- Amy Yang,
- Ying Zhang,
- Nagendra P. Palani,
- Juan E. Abrahante,
- Christopher Burlak,
- Stephen D. Miller,
- Xunrong Luo,
- Bernhard J. Hering
Affiliations
- Amar Singh
- Schulze Diabetes Institute, Department of Surgery, University of Minnesota
- Sabarinathan Ramachandran
- Schulze Diabetes Institute, Department of Surgery, University of Minnesota
- Melanie L. Graham
- Preclinical Research Center, Department of Surgery, University of Minnesota
- Saeed Daneshmandi
- Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine
- David Heller
- Schulze Diabetes Institute, Department of Surgery, University of Minnesota
- Wilma Lucia Suarez-Pinzon
- Schulze Diabetes Institute, Department of Surgery, University of Minnesota
- Appakalai N. Balamurugan
- Schulze Diabetes Institute, Department of Surgery, University of Minnesota
- Jeffrey D. Ansite
- Schulze Diabetes Institute, Department of Surgery, University of Minnesota
- Joshua J. Wilhelm
- Schulze Diabetes Institute, Department of Surgery, University of Minnesota
- Amy Yang
- Biostatistics Collaboration Center, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Ying Zhang
- Minnesota Supercomputing Institute, University of Minnesota
- Nagendra P. Palani
- University of Minnesota Genomics Center
- Juan E. Abrahante
- University of Minnesota Informatics Institute
- Christopher Burlak
- Schulze Diabetes Institute, Department of Surgery, University of Minnesota
- Stephen D. Miller
- Department of Microbiology-Immunology and Interdepartmental Immunology Center, Northwestern University
- Xunrong Luo
- Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine
- Bernhard J. Hering
- Schulze Diabetes Institute, Department of Surgery, University of Minnesota
- DOI
- https://doi.org/10.1038/s41467-019-11338-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Injection of donor apoptotic cells induces graft tolerance in mice. Here the authors combine this approach with short immunosuppressive therapy to achieve long-term tolerance to allogeneic islets and restoration of normoglycemia in diabetic nonhuman primates, and delineate cellular and molecular correlates of tolerance induction.
