Quantitative sensing and signalling of single-stranded DNA during the DNA damage response

Susanne C. S. Bantele; Michael Lisby; Boris Pfander

doi:10.1038/s41467-019-08889-5

Nature Communications (Feb 2019)

Quantitative sensing and signalling of single-stranded DNA during the DNA damage response

Susanne C. S. Bantele,
Michael Lisby,
Boris Pfander

Affiliations

Susanne C. S. Bantele: Max Planck Institute of Biochemistry, DNA Replication and Genome Integrity
Michael Lisby: Department of Biology, University of Copenhagen
Boris Pfander: Max Planck Institute of Biochemistry, DNA Replication and Genome Integrity

DOI: https://doi.org/10.1038/s41467-019-08889-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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DNA damage triggers checkpoint signalling mechanisms. Here the authors reveal differential phosphorylation of targets of the Mec1-Ddc2 checkpoint kinase by analyzing the effect of quantitatively different ssDNA signals.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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