Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

Anat Shemer; Jonathan Grozovski; Tuan Leng Tay; Jenhan Tao; Alon Volaski; Patrick Süß; Alberto Ardura-Fabregat; Mor Gross-Vered; Jung-Seok Kim; Eyal David; Louise Chappell-Maor; Lars Thielecke; Christopher K. Glass; Kerstin Cornils; Marco Prinz; Steffen Jung

doi:10.1038/s41467-018-07548-5

Nature Communications (Dec 2018)

Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

Anat Shemer,
Jonathan Grozovski,
Tuan Leng Tay,
Jenhan Tao,
Alon Volaski,
Patrick Süß,
Alberto Ardura-Fabregat,
Mor Gross-Vered,
Jung-Seok Kim,
Eyal David,
Louise Chappell-Maor,
Lars Thielecke,
Christopher K. Glass,
Kerstin Cornils,
Marco Prinz,
Steffen Jung

Affiliations

Anat Shemer: Department of Immunology, Weizmann Institute of Science
Jonathan Grozovski: Department of Immunology, Weizmann Institute of Science
Tuan Leng Tay: Cluster of Excellence BrainLinks-BrainTools, University of Freiburg
Jenhan Tao: Department of Cellular and Molecular Medicine, University of California, San Diego
Alon Volaski: Department of Immunology, Weizmann Institute of Science
Patrick Süß: Institute of Neuropathology, Medical Faculty, University of Freiburg
Alberto Ardura-Fabregat: Institute of Neuropathology, Medical Faculty, University of Freiburg
Mor Gross-Vered: Department of Immunology, Weizmann Institute of Science
Jung-Seok Kim: Department of Immunology, Weizmann Institute of Science
Eyal David: Department of Immunology, Weizmann Institute of Science
Louise Chappell-Maor: Department of Immunology, Weizmann Institute of Science
Lars Thielecke: Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
Christopher K. Glass: Department of Cellular and Molecular Medicine, University of California, San Diego
Kerstin Cornils: University Medical Center Hamburg-Eppendorf, Department of Pediatric Hematology and Oncology, Division of Pediatric Stem Cell Transplantation and Immunology and Research Institute, Children’s Cancer Center Hamburg
Marco Prinz: Institute of Neuropathology, Medical Faculty, University of Freiburg
Steffen Jung: Department of Immunology, Weizmann Institute of Science

DOI: https://doi.org/10.1038/s41467-018-07548-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

Read online

Irradiation depletes brain microglia cells and induces replenishment of the pool by bone marrow (BM)-derived macrophage. Here the authors show, using mouse BM chimera, that BM-derived macrophages establish long-term residency in the brain, but remain distinct from resident microglia in their transcriptome and gene accessibility landscape.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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