Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci

Abstract

Alternative splicing of mRNAs occurs in tissue specific manners and may be modulated by genetic variations. Here, Takata and colleagues perform splicing quantitative trait loci analysis (sQTL) of human brain and show significant enrichment of sQTLs among neurological disease-associated loci.