PLoS ONE (Jan 2024)

Acute and long-term outcomes of SARS-CoV-2 infection in school-aged children in England: Study protocol for the joint analysis of the COVID-19 schools infection survey (SIS) and the COVID-19 mapping and mitigation in schools (CoMMinS) study.

  • Katharine J Looker,
  • Elliot McClenaghan,
  • Alison Judd,
  • Livia Pierotti,
  • Harriet Downing,
  • Jody Phelan,
  • Charlotte Warren-Gash,
  • Kalu Ngozi,
  • Fiona Dawe,
  • Caroline Relton,
  • Hannah Christensen,
  • Alastair D Hay,
  • Punam Mangtani,
  • Patrick Nguipdop-Djomo,
  • Rachel Denholm

DOI
https://doi.org/10.1371/journal.pone.0303892
Journal volume & issue
Vol. 19, no. 5
p. e0303892

Abstract

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BackgroundThe symptom profiles of acute SARS-CoV-2 infection and long-COVID in children and young people (CYP), risk factors, and associated healthcare needs, are poorly defined. The Schools Infection Survey 1 (SIS-1) was a nationwide study of SARS-CoV-2 infection in primary and secondary schools in England during the 2020/21 school year. The Covid-19 Mapping and Mitigation in Schools (CoMMinS) study was conducted in schools in the Bristol area over a similar period. Both studies conducted testing to identify current and previous SARS-CoV-2 infection, and recorded symptoms and school attendance. These research data have been linked to routine electronic health record (EHR) data.AimsTo better understand the short- and long-term consequences of SARS-CoV-2 infection, and their risk factors, in CYP.MethodsRetrospective cohort and nested case-control analyses will be conducted for SIS-1 and CoMMinS data linked to EHR data for the association between (1) acute symptomatic SARS-CoV-2 infection and risk factors; (2) SARS-CoV-2 infection and long-term effects on health: (a) persistent symptoms; (b) any new diagnosis; (c) a new prescription in primary care; (d) health service attendance; (e) a high rate of school absence.ResultsOur study will improve understanding of long-COVID in CYP by characterising the trajectory of long-COVID in CYP in terms of things like symptoms and diagnoses of conditions. The research will inform which groups of CYP are more likely to get acute- and long-term outcomes of SARS-CoV-2 infection, and patterns of related healthcare-seeking behaviour, relevant for healthcare service planning. Digested information will be produced for affected families, doctors, schools, and the public, as appropriate.ConclusionLinked SIS-1 and CoMMinS data represent a unique and rich resource for understanding the impact of SARS-CoV-2 infection on children's health, benefiting from enhanced SARS-CoV-2 testing and ability to assess a wide range of outcomes.