The Role of Exosomes in Human Carcinogenesis and Cancer Therapy—Recent Findings from Molecular and Clinical Research

Katarzyna Stefańska; Małgorzata Józkowiak; Ana Angelova Volponi; Jamil Awad Shibli; Afsaneh Golkar-Narenji; Paweł Antosik; Dorota Bukowska; Hanna Piotrowska-Kempisty; Paul Mozdziak; Piotr Dzięgiel; Marzenna Podhorska-Okołów; Maciej Zabel; Marta Dyszkiewicz-Konwińska; Bartosz Kempisty

doi:10.3390/cells12030356

Cells (Jan 2023)

The Role of Exosomes in Human Carcinogenesis and Cancer Therapy—Recent Findings from Molecular and Clinical Research

Katarzyna Stefańska,
Małgorzata Józkowiak,
Ana Angelova Volponi,
Jamil Awad Shibli,
Afsaneh Golkar-Narenji,
Paweł Antosik,
Dorota Bukowska,
Hanna Piotrowska-Kempisty,
Paul Mozdziak,
Piotr Dzięgiel,
Marzenna Podhorska-Okołów,
Maciej Zabel,
Marta Dyszkiewicz-Konwińska,
Bartosz Kempisty

Affiliations

Katarzyna Stefańska: Department of Histology and Embryology, Poznan University of Medical Sciences, 60-781 Poznan, Poland
Małgorzata Józkowiak: Department of Toxicology, Poznan University of Medical Sciences, 60-631 Poznan, Poland
Ana Angelova Volponi: Centre for Craniofacial and Regenerative Biology, Dental Institute, King’s College London, London WC2R 2LS, UK
Jamil Awad Shibli: Department of Periodontology and Oral Implantology, University of Guarulhos, Guarulhos 07030-010, Brazil
Afsaneh Golkar-Narenji: Prestage Department of Poultry Sciences, North Carolina State University, Raleigh, NC 27695, USA
Paweł Antosik: Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
Dorota Bukowska: Department of Diagnostics and Clinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
Hanna Piotrowska-Kempisty: Department of Toxicology, Poznan University of Medical Sciences, 60-631 Poznan, Poland
Paul Mozdziak: Prestage Department of Poultry Sciences, North Carolina State University, Raleigh, NC 27695, USA
Piotr Dzięgiel: Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland
Marzenna Podhorska-Okołów: Division of Ultrastructural Research, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland
Maciej Zabel: Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland
Marta Dyszkiewicz-Konwińska: Department of Biomaterials and Experimental Dentistry, Poznan University of Medical Sciences, 60-812 Poznan, Poland
Bartosz Kempisty: Prestage Department of Poultry Sciences, North Carolina State University, Raleigh, NC 27695, USA

DOI: https://doi.org/10.3390/cells12030356
Journal volume & issue: Vol. 12, no. 3
p. 356

Abstract

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Exosomes are biological nanoscale spherical lipid bilayer vesicles, 40–160 nm in diameter, produced by most mammalian cells in both physiological and pathological conditions. Exosomes are formed via the endosomal sorting complex required for transport (ESCRT). The primary function of exosomes is mediating cell-to-cell communication. In terms of cancer, exosomes play important roles as mediators of intercellular communication, leading to tumor progression. Moreover, they can serve as biomarkers for cancer detection and progression. Therefore, their utilization in cancer therapies has been suggested, either as drug delivery carriers or as a diagnostic tool. However, exosomes were also reported to be involved in cancer drug resistance via transferring information of drug resistance to sensitive cells. It is important to consider the current knowledge regarding the role of exosomes in cancer, drug resistance, cancer therapies, and their clinical application in cancer therapies.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

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