Frontiers in Cardiovascular Medicine (Sep 2021)

Relationship Between Immunoinflammation and Coronary Physiology Evaluated by Quantitative Flow Ratio in Patients With Coronary Artery Disease

  • Chengzhe Liu,
  • Chengzhe Liu,
  • Chengzhe Liu,
  • Chengzhe Liu,
  • Zhiyao Yu,
  • Zhiyao Yu,
  • Zhiyao Yu,
  • Zhiyao Yu,
  • Huaqiang Chen,
  • Huaqiang Chen,
  • Huaqiang Chen,
  • Huaqiang Chen,
  • Jun Wang,
  • Jun Wang,
  • Jun Wang,
  • Jun Wang,
  • Wei Liu,
  • Wei Liu,
  • Wei Liu,
  • Wei Liu,
  • Liping Zhou,
  • Liping Zhou,
  • Liping Zhou,
  • Liping Zhou,
  • Yueyi Wang,
  • Yueyi Wang,
  • Yueyi Wang,
  • Yueyi Wang,
  • Hu Chen,
  • Hu Chen,
  • Hu Chen,
  • Hu Chen,
  • Huixin Zhou,
  • Huixin Zhou,
  • Huixin Zhou,
  • Huixin Zhou,
  • Zhihao Liu,
  • Zhihao Liu,
  • Zhihao Liu,
  • Zhihao Liu,
  • Jiapeng Han,
  • Jiapeng Han,
  • Jiapeng Han,
  • Jiapeng Han,
  • Hong Jiang,
  • Hong Jiang,
  • Hong Jiang,
  • Hong Jiang,
  • Lilei Yu,
  • Lilei Yu,
  • Lilei Yu,
  • Lilei Yu

DOI
https://doi.org/10.3389/fcvm.2021.714276
Journal volume & issue
Vol. 8

Abstract

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Background: The association between coronary physiology and immunoinflammation has not been investigated. We performed a retrospective study using quantitative flow ratio (QFR) to evaluate the interaction between immunoinflammatory biomarkers and coronary physiology.Methods: A total of 172 patients with CAD who underwent coronary arteriography (CAG) and QFR were continuously enrolled from May 2020 to February 2021. As a quantitative indicator of coronary physiology, QFR can reflect the functional severity of coronary artery stenosis. The target vessel measured by QFR was defined as that with the most severe lesions. Significant coronary anatomical stenosis was defined as 70% stenosis in the target vessel.Results: Compared with the QFR > 0.8 group, interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ were increased and CD3+ and CD4+ T lymphocyte counts were decreased in the QFR ≤ 0.8 group. In addition, patients with DS ≤ 70% had higher IL-6, IL-10, and TNF-α levels and decreased CD3+ and CD4+ T lymphocyte counts than those with DS > 70%. Logistic regression analysis indicated IL-6 to be an independent predictor of significant coronary functional and anatomic stenosis (odds ratio, 1.125; 95% CI, 1.059–1.196; P < 0.001). Receiver operating characteristic (ROC) analyses showed that IL-6 > 6.36 was predictive of QFR ≤ 0.8 of the target vessel. The combination of IL-6, IL-10 and CD4 improved the value for predicting QFR ≤ 0.8 of the target vessel (AUC, 0.737; 95% CI, 0.661–0.810).Conclusion: Among immunoinflammatory biomarkers, IL-6 was independently associated with a higher risk of QFR ≤ 0.8 of the target vessel. The combination of immunoinflammatory biomarkers was highly predictive of significant coronary functional and anatomic stenosis.

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