Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage

Poyu Chen; Hirotomo Takatsuka; Naoki Takahashi; Rie Kurata; Yoichiro Fukao; Kosuke Kobayashi; Masaki Ito; Masaaki Umeda

doi:10.1038/s41467-017-00676-4

Nature Communications (Sep 2017)

Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage

Poyu Chen,
Hirotomo Takatsuka,
Naoki Takahashi,
Rie Kurata,
Yoichiro Fukao,
Kosuke Kobayashi,
Masaki Ito,
Masaaki Umeda

Affiliations

Poyu Chen: Graduate School of Biological Sciences, Nara Institute of Science and Technology
Hirotomo Takatsuka: Graduate School of Biological Sciences, Nara Institute of Science and Technology
Naoki Takahashi: Graduate School of Biological Sciences, Nara Institute of Science and Technology
Rie Kurata: Graduate School of Biological Sciences, Nara Institute of Science and Technology
Yoichiro Fukao: Department of Bioinformatics, Ritsumeikan University
Kosuke Kobayashi: Graduate School of Bioagricultural Sciences, Nagoya University
Masaki Ito: Graduate School of Bioagricultural Sciences, Nagoya University
Masaaki Umeda: Graduate School of Biological Sciences, Nara Institute of Science and Technology

DOI: https://doi.org/10.1038/s41467-017-00676-4
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

Read online

Inhibition of cell division maintains genome integrity in response to DNA damage. Here Chen et al. propose that DNA damage causes cell cycle arrest in the Arabidopsis root via Rep-MYB transcription factor-mediated repression of G2/M-specific gene expression in response to reduced cyclin-dependent kinase activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal