Nature Communications (Jan 2018)

Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer

  • Hadas Gibori,
  • Shay Eliyahu,
  • Adva Krivitsky,
  • Dikla Ben-Shushan,
  • Yana Epshtein,
  • Galia Tiram,
  • Rachel Blau,
  • Paula Ofek,
  • Joo Sang Lee,
  • Eytan Ruppin,
  • Limor Landsman,
  • Iris Barshack,
  • Talia Golan,
  • Emmanuelle Merquiol,
  • Galia Blum,
  • Ronit Satchi-Fainaro

DOI
https://doi.org/10.1038/s41467-017-02283-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 18

Abstract

Read online

Treatment of pancreatic ductal adenocarcinoma is still challenging and patients survival has only marginally improved in the last decade. Here the authors produce a PGA-based polymeric nanocarrier for the dual delivery of miR-34a-mimic and PLK1-targeting siRNA resulting in killing of pancreatic cancer cells in vivo.