Nature Communications (May 2021)
Transcriptional signature in microglia associated with Aβ plaque phagocytosis
- Alexandra Grubman,
- Xin Yi Choo,
- Gabriel Chew,
- John F. Ouyang,
- Guizhi Sun,
- Nathan P. Croft,
- Fernando J. Rossello,
- Rebecca Simmons,
- Sam Buckberry,
- Dulce Vargas Landin,
- Jahnvi Pflueger,
- Teresa H. Vandekolk,
- Zehra Abay,
- Yichen Zhou,
- Xiaodong Liu,
- Joseph Chen,
- Michael Larcombe,
- John M. Haynes,
- Catriona McLean,
- Sarah Williams,
- Siew Yeen Chai,
- Trevor Wilson,
- Ryan Lister,
- Colin W. Pouton,
- Anthony W. Purcell,
- Owen J. L. Rackham,
- Enrico Petretto,
- Jose M. Polo
Affiliations
- Alexandra Grubman
- Department of Anatomy and Developmental Biology, Monash University
- Xin Yi Choo
- Department of Anatomy and Developmental Biology, Monash University
- Gabriel Chew
- Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School
- John F. Ouyang
- Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School
- Guizhi Sun
- Department of Anatomy and Developmental Biology, Monash University
- Nathan P. Croft
- Department of Biochemistry and Molecular Biology, Monash University
- Fernando J. Rossello
- Department of Anatomy and Developmental Biology, Monash University
- Rebecca Simmons
- ARC Center of Excellence in Plant Energy Biology, The University of Western Australia
- Sam Buckberry
- ARC Center of Excellence in Plant Energy Biology, The University of Western Australia
- Dulce Vargas Landin
- ARC Center of Excellence in Plant Energy Biology, The University of Western Australia
- Jahnvi Pflueger
- ARC Center of Excellence in Plant Energy Biology, The University of Western Australia
- Teresa H. Vandekolk
- Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus)
- Zehra Abay
- Department of Anatomy and Developmental Biology, Monash University
- Yichen Zhou
- Department of Anatomy and Developmental Biology, Monash University
- Xiaodong Liu
- Department of Anatomy and Developmental Biology, Monash University
- Joseph Chen
- Department of Anatomy and Developmental Biology, Monash University
- Michael Larcombe
- Department of Anatomy and Developmental Biology, Monash University
- John M. Haynes
- Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus)
- Catriona McLean
- Victorian Brain Bank
- Sarah Williams
- Department of Anatomy and Developmental Biology, Monash University
- Siew Yeen Chai
- Department of Physiology, Monash University
- Trevor Wilson
- MHTP Medical Genomics Facility
- Ryan Lister
- ARC Center of Excellence in Plant Energy Biology, The University of Western Australia
- Colin W. Pouton
- Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus)
- Anthony W. Purcell
- Department of Biochemistry and Molecular Biology, Monash University
- Owen J. L. Rackham
- Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School
- Enrico Petretto
- Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School
- Jose M. Polo
- Department of Anatomy and Developmental Biology, Monash University
- DOI
- https://doi.org/10.1038/s41467-021-23111-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 22
Abstract
Microglia associated with Aβ plaques may have a distinct transcriptional signature compared to those in plaque-free areas of the brain in Alzheimer’s disease (AD) models. Here the authors show that amyloid plaque phagocytosis is associated with a specific microglia transcriptional signature in a mouse model of AD.
