Кубанский научный медицинский вестник (Feb 2014)
EVALUATION OF EFFECTIVENESS OF MEDICATION THERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AND CHRONIC HEART FAILURE OF FUNCTIONAL CLASS I
Abstract
100 patients with CHF functional class (FC) I against the background of hypertensive disease of stage II with regular left ventricular (LV) ejection fraction (EF) (LVEF≥55%) took part in the research and were randomized into two groups. Group 1 consisted of 51 patients (54,2±22,9 years old) and received metoprolol succinate (Betalok ZOK, «AstraZeneca», Sweden) in a dosage of 78,1±19,3 mg per day. Group 2 consisted of 49 patients (55,4±23,1 years old) and received Quinapril (Accupro, «Pfizer», USA) in a dosage of 17,3± 7,7 mg per day. Initially and 6 months into therapy, the following tests were done: VO2max treadmill test, echocardiography, 6-minute walk test, NT-proBNP test. In order to objectively quantitatively determine regulatory adaptive status (RAS), a cardiorespiratory synchronism test was done. Results of the research showed that both medications improved indices of diastolic function of the LV, however only Quinapril effectively changed its structural and geometric parameters and systolic function. Exercise tolerance increased, NT-proBNP level decreased, VO2max increased, RAS improved only with Quinapril treatment. Therefore Quinapril has the advantage over metoprolol succinate in patients with CHF FC I and regular LVEF against the background of HD of stage II.
