Nature Communications (Jul 2019)
Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
- Marie-Christine Caron,
- Ajit K. Sharma,
- Julia O’Sullivan,
- Logan R. Myler,
- Maria Tedim Ferreira,
- Amélie Rodrigue,
- Yan Coulombe,
- Chantal Ethier,
- Jean-Philippe Gagné,
- Marie-France Langelier,
- John M. Pascal,
- Ilya J. Finkelstein,
- Michael J. Hendzel,
- Guy G. Poirier,
- Jean-Yves Masson
Affiliations
- Marie-Christine Caron
- Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Division
- Ajit K. Sharma
- Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta
- Julia O’Sullivan
- Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Division
- Logan R. Myler
- Department of Molecular Biosciences, University of Texas at Austin
- Maria Tedim Ferreira
- Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center
- Amélie Rodrigue
- Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Division
- Yan Coulombe
- Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Division
- Chantal Ethier
- Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center
- Jean-Philippe Gagné
- Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center
- Marie-France Langelier
- Biochemistry and Molecular Medicine, Université de Montréal
- John M. Pascal
- Biochemistry and Molecular Medicine, Université de Montréal
- Ilya J. Finkelstein
- Department of Molecular Biosciences, University of Texas at Austin
- Michael J. Hendzel
- Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta
- Guy G. Poirier
- Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center
- Jean-Yves Masson
- Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Division
- DOI
- https://doi.org/10.1038/s41467-019-10741-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates local chromatin relaxation and the recruitment of DNA repair factors at double strand breaks site (DSBs). Here the authors reveal that PARP-1 acts as a critical regulator of DNA end resection of DSBs.
