Deciphering highly similar multigene family transcripts from Iso-Seq data with IsoCon

Kristoffer Sahlin; Marta Tomaszkiewicz; Kateryna D. Makova; Paul Medvedev

doi:10.1038/s41467-018-06910-x

Nature Communications (Nov 2018)

Deciphering highly similar multigene family transcripts from Iso-Seq data with IsoCon

Kristoffer Sahlin,
Marta Tomaszkiewicz,
Kateryna D. Makova,
Paul Medvedev

Affiliations

Kristoffer Sahlin: Department of Computer Science and Engineering, Pennsylvania State University
Marta Tomaszkiewicz: Department of Biology, Pennsylvania State University
Kateryna D. Makova: Department of Biology, Pennsylvania State University
Paul Medvedev: Department of Computer Science and Engineering, Pennsylvania State University

DOI: https://doi.org/10.1038/s41467-018-06910-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Transcripts from highly-similar multigene families are challenging to decipher. Here, the authors develop IsoCon, a tool for detecting and reconstructing isoforms from multigene families by analyzing long PacBio Iso-Seq reads.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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