Emerging Infectious Diseases (Oct 2017)

Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

  • Andrey Maryandyshev,
  • Emanuele Pontali,
  • Simon Tiberi,
  • Onno Akkerman,
  • Shashank Ganatra,
  • Tsetan Dorji Sadutshang,
  • Jan-Willem Alffenaar,
  • Rohit Amale,
  • Jai Mullerpattan,
  • Sonam Topgyal,
  • Zarir Farokh Udwadia,
  • Rosella Centis,
  • Lia D’Ambrosio,
  • Giovanni Sotgiu,
  • Giovanni Battista Migliori

DOI
https://doi.org/10.3201/eid2310.170834
Journal volume & issue
Vol. 23, no. 10
pp. 1718 – 1721

Abstract

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We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.

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