Indap hypotensive efficacy, influence on cardiac structural and functional changes, and autoregulation of peripheral artery tonus

Abstract

The aim of the study was to investigate indap hypotensive efficacy, its influence on cardiac structural and functional changes, as well as on vascular tonus autoregulation, among patients with essential arterial hypertension. The participants were 20 patients with essential hypertension, Stage I-II, aged 50,3 ± 6,7. Twenty-four-hour blood pressure monitoring, brain magnetic resonance tomography, heart ultrasonography were performed. Endothelium-dependent and independent vasodilatation of a. brachialis (AB) was measured in reactive hyperemia and nitrate administration tests. After 24-week (6 months) indap therapy, a significant decrease in blood pressure level (24-hour monitoring results) and in left ventricular myocardial mass (from 178,3 ± 49,3g to 165,7 ± 75,1 g, or by 7 %), was registered. The parameters of endothelial vasodilatatory function improved: AB diameter increase rised from 4,3 ± 2, 2 % to 7, 7 ± 4, 2 % (p = 0,002).

Keywords

• arterial hypertension
• left ventricular hypertrophy
• left ventricular myocardial mass
• endothelial dysfunction