Nature Communications (Dec 2021)

Epigenetic loss of heterogeneity from low to high grade localized prostate tumours

  • Sebnem Ece Eksi,
  • Alex Chitsazan,
  • Zeynep Sayar,
  • George V. Thomas,
  • Andrew J. Fields,
  • Ryan P. Kopp,
  • Paul T. Spellman,
  • Andrew C. Adey

DOI
https://doi.org/10.1038/s41467-021-27615-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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High tumour heterogeneity hinders the identification of molecular subtypes in prostate cancer. Here, the authors integrate single-cell chromatin accessibility data with multiplex imaging and reveal distinct chromatin features and transcriptional factor binding signatures in high- and low-grade prostate tumours.