Nature Communications (Nov 2017)
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis
- Ewelina Krzywinska,
- Chahrazade Kantari-Mimoun,
- Yann Kerdiles,
- Michal Sobecki,
- Takayuki Isagawa,
- Dagmar Gotthardt,
- Magali Castells,
- Johannes Haubold,
- Corinne Millien,
- Thomas Viel,
- Bertrand Tavitian,
- Norihiko Takeda,
- Joachim Fandrey,
- Eric Vivier,
- Veronika Sexl,
- Christian Stockmann
Affiliations
- Ewelina Krzywinska
- Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Cardiovascular Research Center
- Chahrazade Kantari-Mimoun
- Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Cardiovascular Research Center
- Yann Kerdiles
- Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université UM2
- Michal Sobecki
- Institut de Biologie Intégrative de la Cellule (I2BC), Genome Biology, CEA/CNRS/Université Paris Sud
- Takayuki Isagawa
- Graduate School of Biomedical Science, Nagasaki University
- Dagmar Gotthardt
- Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna
- Magali Castells
- Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Cardiovascular Research Center
- Johannes Haubold
- Institut für Physiologie, Universitätsklinikum Essen, Universität Duisburg-Essen
- Corinne Millien
- Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Cardiovascular Research Center
- Thomas Viel
- Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Cardiovascular Research Center
- Bertrand Tavitian
- Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Cardiovascular Research Center
- Norihiko Takeda
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Joachim Fandrey
- Institut für Physiologie, Universitätsklinikum Essen, Universität Duisburg-Essen
- Eric Vivier
- Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université UM2
- Veronika Sexl
- Institut de Biologie Intégrative de la Cellule (I2BC), Genome Biology, CEA/CNRS/Université Paris Sud
- Christian Stockmann
- Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Cardiovascular Research Center
- DOI
- https://doi.org/10.1038/s41467-017-01599-w
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Tumour hypoxia influences both the immune responses and angiogenesis. Here, the authors show that HIF-1α deletion in NK cells impairs NK cytotoxic activity but inhibit tumour growth by decreasing the infiltration of NK cells that express angiostatic soluble VEGFR-1, thus resulting in non-functional angiogenesis.
