Central nervous system virion detection in acute measles: histopathological, ultrastructural and pathogenetic aspects Detecção de partículas virais no SNC no sarampo agudo: aspectos histopatológicos, ultraestruturais e patogenéticos

Abstract

Histopathological and ultrastructural studies of 23 patients who died with clinical diagnosis of measles were carried out. In 12 cases viral nucleocapsids were searched by electron microscopy and detected in 100% of the cases in the lungs and in 50% of the cases in the central nervous system. They were mostly intranuclear. Histopathological changes associated to neurological alterations and the detection of virion are discussed in relation to acute and delayed clinical manifestations.Foram realizados estudos histopatológicos e ultraestruturais de 23 pacientes que morreram com diagnóstico clínico de sarampo. Presença de nucleo-capsides virais foi pesquisada em 12 casos e detectada em 50% destes casos no SNC. Eram, na maioria dos casos, intranucleares. As alterações histopatológicas associadas a manifestações neurológicas e à detecção do vírus são discutidas em relação às manifestações clínicas agudas e tardias.

Keywords

• Measles
• Virus
• Central Nervous System
• Pathology
• Ultrastructure
• Pathogenesis