Helix 8 is the essential structural motif of mechanosensitive GPCRs

Serap Erdogmus; Ursula Storch; Laura Danner; Jasmin Becker; Michaela Winter; Nicole Ziegler; Angela Wirth; Stefan Offermanns; Carsten Hoffmann; Thomas Gudermann; Michael Mederos y Schnitzler

doi:10.1038/s41467-019-13722-0

Nature Communications (Dec 2019)

Helix 8 is the essential structural motif of mechanosensitive GPCRs

Serap Erdogmus,
Ursula Storch,
Laura Danner,
Jasmin Becker,
Michaela Winter,
Nicole Ziegler,
Angela Wirth,
Stefan Offermanns,
Carsten Hoffmann,
Thomas Gudermann,
Michael Mederos y Schnitzler

Affiliations

Serap Erdogmus: Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich
Ursula Storch: Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich
Laura Danner: Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich
Jasmin Becker: Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich
Michaela Winter: Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich
Nicole Ziegler: Institute of Pharmacology and Toxicology, Julius Maximilian University of Würzburg
Angela Wirth: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Stefan Offermanns: Max Planck Institute for Heart and Lung Research, Department of Pharmacology
Carsten Hoffmann: Institute for Molecular Cell Biology, Center for Molecular Biomedicine, Friedrich Schiller University Jena
Thomas Gudermann: Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich
Michael Mederos y Schnitzler: Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilian University of Munich

DOI: https://doi.org/10.1038/s41467-019-13722-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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GPCRs are versatile cellular sensors for chemical stimuli but the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive. Here authors identify the C-terminal helix 8 (H8) as the essential structural motif endowing H1R and other GPCRs with mechanosensitivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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