Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1

Radoslaw Pluta; Eric Aragón; Nicholas A. Prescott; Lidia Ruiz; Rebeca A. Mees; Blazej Baginski; Julia R. Flood; Pau Martin-Malpartida; Joan Massagué; Yael David; Maria J. Macias

doi:10.1038/s41467-022-34925-y

Nature Communications (Nov 2022)

Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1

Radoslaw Pluta,
Eric Aragón,
Nicholas A. Prescott,
Lidia Ruiz,
Rebeca A. Mees,
Blazej Baginski,
Julia R. Flood,
Pau Martin-Malpartida,
Joan Massagué,
Yael David,
Maria J. Macias

Affiliations

Radoslaw Pluta: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)
Eric Aragón: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)
Nicholas A. Prescott: Tri-Institutional PhD Program in Chemical Biology
Lidia Ruiz: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)
Rebeca A. Mees: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)
Blazej Baginski: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)
Julia R. Flood: Chemical Biology Program, Memorial Sloan Kettering Cancer Center
Pau Martin-Malpartida: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)
Joan Massagué: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
Yael David: Chemical Biology Program, Memorial Sloan Kettering Cancer Center
Maria J. Macias: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST)

DOI: https://doi.org/10.1038/s41467-022-34925-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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FoxH1 is an essential maternal pioneer factor during embryonic development. Here, the authors present several FoxH1—DNA structures that reveal the molecular basis for FoxH1 binding specificity and pioneer factor activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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