The mast cell: A Janus in kidney transplants

G. van der Elst; H. Varol; M. Hermans; C. C. Baan; J. P. Duong-van Huyen; D. A. Hesselink; R. Kramann; R. Kramann; R. Kramann; M. Rabant; M. E. J. Reinders; J. H. von der Thüsen; T. P. P. van den Bosch; M. C. Clahsen-van Groningen; M. C. Clahsen-van Groningen

doi:10.3389/fimmu.2023.1122409

Frontiers in Immunology (Feb 2023)

The mast cell: A Janus in kidney transplants

G. van der Elst,
H. Varol,
M. Hermans,
C. C. Baan,
J. P. Duong-van Huyen,
D. A. Hesselink,
R. Kramann,
R. Kramann,
R. Kramann,
M. Rabant,
M. E. J. Reinders,
J. H. von der Thüsen,
T. P. P. van den Bosch,
M. C. Clahsen-van Groningen,
M. C. Clahsen-van Groningen

Affiliations

G. van der Elst: Department of Pathology and Clinical Bioinformatics, Erasmus University Center Rotterdam, Rotterdam, Netherlands
H. Varol: Department of Pathology and Clinical Bioinformatics, Erasmus University Center Rotterdam, Rotterdam, Netherlands
M. Hermans: Department of Internal Medicine, Division of Allergy and Clinical Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
C. C. Baan: Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
J. P. Duong-van Huyen: Department of Pathology, Necker Hospital, APHP, Paris, France
D. A. Hesselink: Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
R. Kramann: Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
R. Kramann: Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany
R. Kramann: Division of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany
M. Rabant: Department of Pathology, Necker Hospital, APHP, Paris, France
M. E. J. Reinders: Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
J. H. von der Thüsen: Department of Pathology and Clinical Bioinformatics, Erasmus University Center Rotterdam, Rotterdam, Netherlands
T. P. P. van den Bosch: Department of Pathology and Clinical Bioinformatics, Erasmus University Center Rotterdam, Rotterdam, Netherlands
M. C. Clahsen-van Groningen: Department of Pathology and Clinical Bioinformatics, Erasmus University Center Rotterdam, Rotterdam, Netherlands
M. C. Clahsen-van Groningen: Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany

DOI: https://doi.org/10.3389/fimmu.2023.1122409
Journal volume & issue: Vol. 14

Abstract

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Mast cells (MCs) are innate immune cells with a versatile set of functionalities, enabling them to orchestrate immune responses in various ways. Aside from their known role in allergy, they also partake in both allograft tolerance and rejection through interaction with regulatory T cells, effector T cells, B cells and degranulation of cytokines and other mediators. MC mediators have both pro- and anti-inflammatory actions, but overall lean towards pro-fibrotic pathways. Paradoxically, they are also seen as having potential protective effects in tissue remodeling post-injury. This manuscript elaborates on current knowledge of the functional diversity of mast cells in kidney transplants, combining theory and practice into a MC model stipulating both protective and harmful capabilities in the kidney transplant setting.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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