Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus

Daniele Suzete Persike; Rodrigo Luiz Oliveira Rodrigues Cunha; Luiz Juliano; Iara Ribeiro Silva; Fernanda Elisa Rosim; Thiago Vignoli; Flavia Dona; Esper Abrão Cavalheiro; Maria José da Silva Fernandes

Neurobiology of Disease (Jul 2008)

Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus

Daniele Suzete Persike,
Rodrigo Luiz Oliveira Rodrigues Cunha,
Luiz Juliano,
Iara Ribeiro Silva,
Fernanda Elisa Rosim,
Thiago Vignoli,
Flavia Dona,
Esper Abrão Cavalheiro,
Maria José da Silva Fernandes

Affiliations

Daniele Suzete Persike: Disciplina de Neurologia Experimental, Departamento Neurologia/Neurocirurgia, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
Rodrigo Luiz Oliveira Rodrigues Cunha: Departamento de Biofísica, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
Luiz Juliano: Departamento de Biofísica, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
Iara Ribeiro Silva: Disciplina de Neurologia Experimental, Departamento Neurologia/Neurocirurgia, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
Fernanda Elisa Rosim: Disciplina de Neurologia Experimental, Departamento Neurologia/Neurocirurgia, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
Thiago Vignoli: Disciplina de Neurologia Experimental, Departamento Neurologia/Neurocirurgia, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
Flavia Dona: Disciplina de Neurologia Experimental, Departamento Neurologia/Neurocirurgia, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
Esper Abrão Cavalheiro: Disciplina de Neurologia Experimental, Departamento Neurologia/Neurocirurgia, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
Maria José da Silva Fernandes: Disciplina de Neurologia Experimental, Departamento Neurologia/Neurocirurgia, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil; Corresponding author. Departamento de Neurologia e Neurocirurgia, Disciplina de Neurologia Experimental, Universidade Federal de São Paulo, Rua Pedro de Toledo, 781–60 andar, CEP: 04039-032, São Paulo, Brazil. Fax: +55 11 55494743.

Journal volume & issue: Vol. 31, no. 1
pp. 120 – 126

Abstract

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Temporal lobe epilepsy is the most common form of epilepsy in humans. Caspase activation is a mechanism of cell death induced by seizures. Tellurium (IV) compounds present antitumoral, immunomodulatory and neuroprotective effects due to their ability to inhibit cysteine proteases. We studied the activity of caspase-1, -3 and -8 in the hippocampus of rats exhibiting status epilepticus induced by pilocarpine. All three caspases were activated. Tellurium (IV) compounds RF-07, RF-03 and AS-101 inhibited caspases in vitro, showing high second-order inhibition rate constants. The intraperitoneal injection of RF-07 prior to pilocarpine suppressed the behavioral and electroencephalographic seizure occurrence. According to our results, the caspases are activated as early as 90 min following SE. Tellurium (IV) compounds exerted anticonvulsant effects associated with the inhibition of caspases. These results suggest a promising therapeutic potential of organotellurium (IV) compounds as antiepileptogenic agents.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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