Longitudinal hippocampal atrophy in hippocampal sclerosis of aging

Janice X. Li; Hannah L. Nguyen; Tianchen Qian; Davis C. Woodworth; S. Ahmad Sajjadi

Aging Brain (Jan 2023)

Longitudinal hippocampal atrophy in hippocampal sclerosis of aging

Janice X. Li,
Hannah L. Nguyen,
Tianchen Qian,
Davis C. Woodworth,
S. Ahmad Sajjadi

Affiliations

Janice X. Li: Department of Neurology, University of California, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA
Hannah L. Nguyen: Department of Neurology, University of California, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA
Tianchen Qian: Department of Statistics, University of California, Irvine, Irvine, CA, USA
Davis C. Woodworth: Department of Neurology, University of California, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA
S. Ahmad Sajjadi: Department of Neurology, University of California, Irvine, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA; Department of Pathology, University of California, Irvine, CA, USA; Corresponding author at: University of California, Irvine, Office 364, Med Surge II Building, Irvine 92697, USA.

Journal volume & issue: Vol. 4
p. 100092

Abstract

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Hippocampal sclerosis of aging (HS-A) is a common degenerative neuropathology in older individuals and is associated with dementia. HS-A is characterized by disproportionate hippocampal atrophy at autopsy but cannot be diagnosed during life. Therefore, little is known about the onset and progression of hippocampal atrophy in individuals with HS-A. To better understand the onset and progression of hippocampal atrophy in HS-A, we examined longitudinal hippocampal atrophy using serial MRI in participants with HS-A at autopsy (HS-A+, n = 8) compared to participants with limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) without HS-A (n = 13), Alzheimer’s disease neuropathologic change (ADNC) without HS-A or LATE-NC (n = 16), and those without these pathologies (n = 7). We found that participants with HS-A had lower hippocampal volumes compared to the other groups, and this atrophy preceded the onset of dementia. There was also some evidence that rates of hippocampal volume loss were slightly slower in those with HS-A. Together, these results suggest that the disproportionate hippocampal atrophy seen in HS-A may begin early prior to dementia.

Published in Aging Brain

ISSN: 2589-9589 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/aging-brain

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Abstract

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