Nature Communications (May 2022)
Mutational landscape of normal epithelial cells in Lynch Syndrome patients
- Bernard C. H. Lee,
- Philip S. Robinson,
- Tim H. H. Coorens,
- Helen H. N. Yan,
- Sigurgeir Olafsson,
- Henry Lee-Six,
- Mathijs A. Sanders,
- Hoi Cheong Siu,
- James Hewinson,
- Sarah S. K. Yue,
- Wai Yin Tsui,
- Annie S. Y. Chan,
- Anthony K. W. Chan,
- Siu Lun Ho,
- Peter J. Campbell,
- Inigo Martincorena,
- Simon J. A. Buczacki,
- Siu Tsan Yuen,
- Suet Yi Leung,
- Michael R. Stratton
Affiliations
- Bernard C. H. Lee
- Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital
- Philip S. Robinson
- Wellcome Sanger Institute
- Tim H. H. Coorens
- Wellcome Sanger Institute
- Helen H. N. Yan
- Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital
- Sigurgeir Olafsson
- Wellcome Sanger Institute
- Henry Lee-Six
- Wellcome Sanger Institute
- Mathijs A. Sanders
- Wellcome Sanger Institute
- Hoi Cheong Siu
- Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital
- James Hewinson
- Wellcome Sanger Institute
- Sarah S. K. Yue
- Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital
- Wai Yin Tsui
- Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital
- Annie S. Y. Chan
- Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital
- Anthony K. W. Chan
- Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital
- Siu Lun Ho
- Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital
- Peter J. Campbell
- Wellcome Sanger Institute
- Inigo Martincorena
- Wellcome Sanger Institute
- Simon J. A. Buczacki
- Nuffield Department of Surgical Sciences, University of Oxford, Headington
- Siu Tsan Yuen
- Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital
- Suet Yi Leung
- Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital
- Michael R. Stratton
- Wellcome Sanger Institute
- DOI
- https://doi.org/10.1038/s41467-022-29920-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
It is unclear whether somatic mutation rates are elevated in Lynch Syndrome (LS), which is the most common cause of hereditary colorectal cancer. Here, the authors use whole-genome sequencing and organoid cultures to show that normal tissues in LS patients are genomically stable, while ancestor cells of neoplastic tissues undergo multiple cycles of clonal evolution.
