Acute disseminated encephalomyelitis (ADEM) after SARS- CoV-2 vaccination: A case report

Fereshteh Yazdanpanah, MD; Pooya Iranpour, MD; Sara Haseli, MD; Maryam Poursadeghfard, MD; Fatemeh Yarmahmoodi, MD

Radiology Case Reports (May 2022)

Acute disseminated encephalomyelitis (ADEM) after SARS- CoV-2 vaccination: A case report

Fereshteh Yazdanpanah, MD,
Pooya Iranpour, MD,
Sara Haseli, MD,
Maryam Poursadeghfard, MD,
Fatemeh Yarmahmoodi, MD

Affiliations

Fereshteh Yazdanpanah, MD: Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tabriz, Iran
Pooya Iranpour, MD: Medical Imaging Research center, Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran
Sara Haseli, MD: Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
Maryam Poursadeghfard, MD: Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Fatemeh Yarmahmoodi, MD: Medical Imaging Research center, Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran; Corresponding author.

Journal volume & issue: Vol. 17, no. 5
pp. 1789 – 1793

Abstract

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Acute disseminated encephalomyelitis (ADEM) is an acute demyelinating disorder of the central nervous system that is ordinarily monophasic. ADEM can develop following infection or vaccination. Here, we present a 37 y/o male patient with progressive muscle weakness in all limbs along with dysphagia following COVID-19 vaccination. Brain magnetic resonance imaging (MRI) revealed typical imaging findings which presented as multifocal T2-FLAIR signal changes in the corticospinal tract, pons, and temporal lobe with diffusion restriction. Magnetic resonance spectroscopy (MRS) further confirmed the diagnosis by the typical elevation of the Choline and Myoinositol peaks. Neurologic impairments have been reported as the potential side effects of COVID-19 vaccines. Appropriate imaging modalities together with a thorough clinical examination are essential for making a correct diagnosis.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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