CO2-sensitive tRNA modification associated with human mitochondrial disease

Huan Lin; Kenjyo Miyauchi; Tai Harada; Ryo Okita; Eri Takeshita; Hirofumi Komaki; Kaoru Fujioka; Hideki Yagasaki; Yu-ichi Goto; Kaori Yanaka; Shinichi Nakagawa; Yuriko Sakaguchi; Tsutomu Suzuki

doi:10.1038/s41467-018-04250-4

Nature Communications (May 2018)

CO2-sensitive tRNA modification associated with human mitochondrial disease

Huan Lin,
Kenjyo Miyauchi,
Tai Harada,
Ryo Okita,
Eri Takeshita,
Hirofumi Komaki,
Kaoru Fujioka,
Hideki Yagasaki,
Yu-ichi Goto,
Kaori Yanaka,
Shinichi Nakagawa,
Yuriko Sakaguchi,
Tsutomu Suzuki

Affiliations

Huan Lin: Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
Kenjyo Miyauchi: Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
Tai Harada: Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
Ryo Okita: Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
Eri Takeshita: Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
Hirofumi Komaki: Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
Kaoru Fujioka: Department of Pediatrics, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
Hideki Yagasaki: Department of Pediatrics, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
Yu-ichi Goto: Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry
Kaori Yanaka: RNA Biology Laboratory, RIKEN Advanced Research Institute
Shinichi Nakagawa: RNA Biology Laboratory, RIKEN Advanced Research Institute
Yuriko Sakaguchi: Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
Tsutomu Suzuki: Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo

DOI: https://doi.org/10.1038/s41467-018-04250-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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Transfer RNA modifications play critical roles in protein synthesis. Here the authors reveal the t6A37 tRNA modification is dynamically regulated by sensing intracellular CO2 concentration in mitochondria, implying metabolic regulation of protein synthesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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