Communications Biology (Feb 2021)
DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association
- Vanessa Lakis,
- Rita T. Lawlor,
- Felicity Newell,
- Ann-Marie Patch,
- Andrea Mafficini,
- Anguraj Sadanandam,
- Lambros T. Koufariotis,
- Rebecca L. Johnston,
- Conrad Leonard,
- Scott Wood,
- Borislav Rusev,
- Vincenzo Corbo,
- Claudio Luchini,
- Sara Cingarlini,
- Luca Landoni,
- Roberto Salvia,
- Michele Milella,
- David Chang,
- Peter Bailey,
- Nigel B. Jamieson,
- Fraser Duthie,
- Marie-Claude Gingras,
- Donna M. Muzny,
- David A. Wheeler,
- Richard A. Gibbs,
- Massimo Milione,
- APGI,
- ARC-Net,
- Paolo Pederzoli,
- Jaswinder S. Samra,
- Anthony J. Gill,
- Amber L. Johns,
- John V. Pearson,
- Andrew V. Biankin,
- Sean M. Grimmond,
- Nicola Waddell,
- Katia Nones,
- Aldo Scarpa
Affiliations
- Vanessa Lakis
- QIMR Berghofer Medical Research Institute
- Rita T. Lawlor
- ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona
- Felicity Newell
- QIMR Berghofer Medical Research Institute
- Ann-Marie Patch
- QIMR Berghofer Medical Research Institute
- Andrea Mafficini
- ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona
- Anguraj Sadanandam
- Division of Molecular Pathology, The Institute of Cancer Research
- Lambros T. Koufariotis
- QIMR Berghofer Medical Research Institute
- Rebecca L. Johnston
- QIMR Berghofer Medical Research Institute
- Conrad Leonard
- QIMR Berghofer Medical Research Institute
- Scott Wood
- QIMR Berghofer Medical Research Institute
- Borislav Rusev
- ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona
- Vincenzo Corbo
- ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona
- Claudio Luchini
- ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona
- Sara Cingarlini
- ENETS Center of Excellence, University and Hospital Trust of Verona
- Luca Landoni
- ENETS Center of Excellence, University and Hospital Trust of Verona
- Roberto Salvia
- ENETS Center of Excellence, University and Hospital Trust of Verona
- Michele Milella
- ENETS Center of Excellence, University and Hospital Trust of Verona
- David Chang
- Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow
- Peter Bailey
- Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow
- Nigel B. Jamieson
- Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow
- Fraser Duthie
- Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow
- Marie-Claude Gingras
- Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine
- Donna M. Muzny
- Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine
- David A. Wheeler
- Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine
- Richard A. Gibbs
- Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine
- Massimo Milione
- Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
- APGI
- ARC-Net
- Paolo Pederzoli
- Ospedale Pederzoli, Peschiera del Garda
- Jaswinder S. Samra
- University of Sydney
- Anthony J. Gill
- University of Sydney
- Amber L. Johns
- The Kinghorn Cancer Centre, Garvan Institute of Medical Research
- John V. Pearson
- QIMR Berghofer Medical Research Institute
- Andrew V. Biankin
- Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow
- Sean M. Grimmond
- University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre
- Nicola Waddell
- QIMR Berghofer Medical Research Institute
- Katia Nones
- QIMR Berghofer Medical Research Institute
- Aldo Scarpa
- ARC-Net Centre for Applied Research on Cancer, University and Hospital Trust of Verona
- DOI
- https://doi.org/10.1038/s42003-020-01469-0
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 11
Abstract
Lakis et al. report novel findings related to the epigenetic landscape of pancreatic neuroendocrine cancer. This relatively large cohort provides functional insights into the epigenetic wiring of pancreatic neuroendocrine tumor sub-types with the potential ability to stratify tumours of different prognosis.
