Synthesis and characterization of a series of 1,3,5-trisubstituted-2-pyrazolines derivatives using methanoic acid under thermal condition

Abstract

An efficient and practical synthesis of 1,3,5-trisubstituted 2-pyrazoline structures was achieved through cyclization of phenylhydrazine with ,-unsaturated ketones (chalcones) using methanoic acid (formic acid) as catalyst under thermal condition.

Keywords

• 1
• 3
• 5-trisubstituted-2-pyrazoline
• phenylhydrazine
• chalcone
• methanoic acid
• heterocyclic synthesis.