Nature Communications (Nov 2016)
MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment
- RaeAnna Wilson,
- Cristina Espinosa-Diez,
- Nathan Kanner,
- Namita Chatterjee,
- Rebecca Ruhl,
- Christina Hipfinger,
- Sunil J. Advani,
- Jie Li,
- Omar F. Khan,
- Aleksandra Franovic,
- Sara M. Weis,
- Sushil Kumar,
- Lisa M. Coussens,
- Daniel G. Anderson,
- Clark C. Chen,
- David A. Cheresh,
- Sudarshan Anand
Affiliations
- RaeAnna Wilson
- Department of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science University
- Cristina Espinosa-Diez
- Department of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science University
- Nathan Kanner
- Department of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science University
- Namita Chatterjee
- Department of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science University
- Rebecca Ruhl
- Department of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science University
- Christina Hipfinger
- Department of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science University
- Sunil J. Advani
- Department of Radiation Medicine and Applied Sciences, University of California
- Jie Li
- Department of Neurosurgery, University of California
- Omar F. Khan
- Department of Chemical Engineering, Institute for Medical Engineering and Science, David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Aleksandra Franovic
- Department of Pathology at the UC San Diego Moores Cancer Center and Sanford Consortium for Regenerative Medicine, University of California
- Sara M. Weis
- Department of Pathology at the UC San Diego Moores Cancer Center and Sanford Consortium for Regenerative Medicine, University of California
- Sushil Kumar
- Department of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science University
- Lisa M. Coussens
- Department of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science University
- Daniel G. Anderson
- Department of Chemical Engineering, Institute for Medical Engineering and Science, David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Clark C. Chen
- Department of Neurosurgery, University of California
- David A. Cheresh
- Department of Pathology at the UC San Diego Moores Cancer Center and Sanford Consortium for Regenerative Medicine, University of California
- Sudarshan Anand
- Department of Cell, Department of Radiation Medicine, Developmental and Cancer Biology, Oregon Health and Science University
- DOI
- https://doi.org/10.1038/ncomms13597
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
The tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here the authors show that radiation induced miR-103 downregulates TREX1 in endothelial cells, decreases angiogenesis and leads to the secretion of proinflammatory mediators that reduce tumour growth.
