Microwave assisted synthesis of 4-quinolones and N,N′-diarylureas

Abstract

4-Quinolinones are an important class of alkaloids, widely used as conventional drugs to treat various infectious diseases. In this study, we report the synthesis of 4-quinolones in one step, under microwave irradiation and with diphenyl ether as a solvent, using ethyl acetoacetate and electron rich anilines. When anilines containing alkyl or electron withdrawing substituents were employed, only N,N′-diarylureas were obtained in moderate to good yields.

Keywords

• 4-quinolinones
• microwave
• n,n′-diarylureas