Nature Communications (Jul 2020)
Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription
- Mami Oikawa,
- Angela Simeone,
- Eva Hormanseder,
- Marta Teperek,
- Vincent Gaggioli,
- Alan O’Doherty,
- Emma Falk,
- Matthieu Sporniak,
- Clive D’Santos,
- Valar Nila Roamio Franklin,
- Kamal Kishore,
- Charles R. Bradshaw,
- Declan Keane,
- Thomas Freour,
- Laurent David,
- Adrian T. Grzybowski,
- Alexander J. Ruthenburg,
- John Gurdon,
- Jerome Jullien
Affiliations
- Mami Oikawa
- Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
- Angela Simeone
- Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
- Eva Hormanseder
- Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
- Marta Teperek
- Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
- Vincent Gaggioli
- Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
- Alan O’Doherty
- UCD School of Agriculture and Food Science, University College Dublin
- Emma Falk
- CRTI, INSERM, UNIV Nantes
- Matthieu Sporniak
- CRTI, INSERM, UNIV Nantes
- Clive D’Santos
- Cancer Research UK Cambridge Institute, University of Cambridge
- Valar Nila Roamio Franklin
- Cancer Research UK Cambridge Institute, University of Cambridge
- Kamal Kishore
- Cancer Research UK Cambridge Institute, University of Cambridge
- Charles R. Bradshaw
- Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
- Declan Keane
- ReproMed Ireland
- Thomas Freour
- Service de Biologie de la Reproduction, CHU Nantes
- Laurent David
- CRTI, INSERM, UNIV Nantes
- Adrian T. Grzybowski
- Department of Molecular Genetics and Cell Biology, The University of Chicago
- Alexander J. Ruthenburg
- Department of Molecular Genetics and Cell Biology, The University of Chicago
- John Gurdon
- Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
- Jerome Jullien
- Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-020-17238-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
In addition to paternal genetic material, sperm contributes epigenetic information to the embryo to efficiently support development. Here, the authors demonstrate a homogeneous paternal contribution to epigenetic information via sperm-derived modified histone transmission to the developing vertebrate embryo.
