Nature Communications (Feb 2020)
Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma
- Elena Galvani,
- Piyushkumar A. Mundra,
- Sara Valpione,
- Pablo Garcia-Martinez,
- Matthew Smith,
- Jonathan Greenall,
- Rohit Thakur,
- Beth Helmink,
- Miles C. Andrews,
- Louis Boon,
- Christopher Chester,
- Gabriela Gremel,
- Kate Hogan,
- Amit Mandal,
- Kang Zeng,
- Antonia Banyard,
- Garry Ashton,
- Martin Cook,
- Paul Lorigan,
- Jennifer A. Wargo,
- Nathalie Dhomen,
- Richard Marais
Affiliations
- Elena Galvani
- Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
- Piyushkumar A. Mundra
- Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
- Sara Valpione
- Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
- Pablo Garcia-Martinez
- Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
- Matthew Smith
- Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
- Jonathan Greenall
- Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
- Rohit Thakur
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Beth Helmink
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Miles C. Andrews
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Louis Boon
- Bioceros B.V
- Christopher Chester
- Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
- Gabriela Gremel
- Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
- Kate Hogan
- Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
- Amit Mandal
- Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
- Kang Zeng
- Imaging and Cytometry, Cancer Research UK Manchester Institute, The University of Manchester
- Antonia Banyard
- Imaging and Cytometry, Cancer Research UK Manchester Institute, The University of Manchester
- Garry Ashton
- Histology, Cancer Research UK Manchester Institute, The University of Manchester
- Martin Cook
- Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
- Paul Lorigan
- The Christie NHS Foundation Trust
- Jennifer A. Wargo
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Nathalie Dhomen
- Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
- Richard Marais
- Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester
- DOI
- https://doi.org/10.1038/s41467-020-14632-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 9
Abstract
Identification of clinical relevant biomarkers to predict response to immune checkpoint blockade (ICB) in melanoma remains challenging. Here, the authors show that stroma remodelling and reduced cell division are associated with durable response to anti-PD1 in a mouse model of melanoma and in ICB-treated patients.
