Nature Communications (Aug 2022)
Clonal diversification and histogenesis of malignant germ cell tumours
- Thomas R. W. Oliver,
- Lia Chappell,
- Rashesh Sanghvi,
- Lauren Deighton,
- Naser Ansari-Pour,
- Stefan C. Dentro,
- Matthew D. Young,
- Tim H. H. Coorens,
- Hyunchul Jung,
- Tim Butler,
- Matthew D. C. Neville,
- Daniel Leongamornlert,
- Mathijs A. Sanders,
- Yvette Hooks,
- Alex Cagan,
- Thomas J. Mitchell,
- Isidro Cortes-Ciriano,
- Anne Y. Warren,
- David C. Wedge,
- Rakesh Heer,
- Nicholas Coleman,
- Matthew J. Murray,
- Peter J. Campbell,
- Raheleh Rahbari,
- Sam Behjati
Affiliations
- Thomas R. W. Oliver
- Wellcome Sanger Institute
- Lia Chappell
- Wellcome Sanger Institute
- Rashesh Sanghvi
- Wellcome Sanger Institute
- Lauren Deighton
- Wellcome Sanger Institute
- Naser Ansari-Pour
- Big Data Institute, Nuffield Department of Medicine, University of Oxford
- Stefan C. Dentro
- Wellcome Sanger Institute
- Matthew D. Young
- Wellcome Sanger Institute
- Tim H. H. Coorens
- Wellcome Sanger Institute
- Hyunchul Jung
- Wellcome Sanger Institute
- Tim Butler
- Wellcome Sanger Institute
- Matthew D. C. Neville
- Wellcome Sanger Institute
- Daniel Leongamornlert
- Wellcome Sanger Institute
- Mathijs A. Sanders
- Wellcome Sanger Institute
- Yvette Hooks
- Wellcome Sanger Institute
- Alex Cagan
- Wellcome Sanger Institute
- Thomas J. Mitchell
- Wellcome Sanger Institute
- Isidro Cortes-Ciriano
- European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI)
- Anne Y. Warren
- Cambridge University Hospitals NHS Foundation Trust
- David C. Wedge
- Big Data Institute, Nuffield Department of Medicine, University of Oxford
- Rakesh Heer
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Nicholas Coleman
- Cambridge University Hospitals NHS Foundation Trust
- Matthew J. Murray
- Cambridge University Hospitals NHS Foundation Trust
- Peter J. Campbell
- Wellcome Sanger Institute
- Raheleh Rahbari
- Wellcome Sanger Institute
- Sam Behjati
- Wellcome Sanger Institute
- DOI
- https://doi.org/10.1038/s41467-022-31375-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
The molecular characterisation of germ cell tumours (GCT) is necessary to understand their development and histological diversification. Here, the authors use whole-genome and transcriptome sequencing of GCTs across distinct histologies to reveal their somatic evolution and clonal diversification, as well as identify several putative biomarkers for treatment stratification.
