Nature Communications (Mar 2023)
Genomic characterization of DICER1-associated neoplasms uncovers molecular classes
- Felix K. F. Kommoss,
- Anne-Sophie Chong,
- Anne-Laure Chong,
- Elke Pfaff,
- David T. W. Jones,
- Laura S. Hiemcke-Jiwa,
- Lennart A. Kester,
- Uta Flucke,
- Manfred Gessler,
- Daniel Schrimpf,
- Felix Sahm,
- Blaise A. Clarke,
- Colin J. R. Stewart,
- Yemin Wang,
- C. Blake Gilks,
- Friedrich Kommoss,
- David G. Huntsman,
- Ulrich Schüller,
- Christian Koelsche,
- W. Glenn McCluggage,
- Andreas von Deimling,
- William D. Foulkes
Affiliations
- Felix K. F. Kommoss
- Institute of Pathology, Heidelberg University Hospital
- Anne-Sophie Chong
- Department of Human Genetics, McGill University
- Anne-Laure Chong
- Department of Human Genetics, McGill University
- Elke Pfaff
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- David T. W. Jones
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Laura S. Hiemcke-Jiwa
- Department of Pathology, University Medical Centre Utrecht
- Lennart A. Kester
- Princess Máxima Center for Pediatric Oncology
- Uta Flucke
- Princess Máxima Center for Pediatric Oncology
- Manfred Gessler
- Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, Würzburg University & Comprehensive Cancer Center Mainfranken
- Daniel Schrimpf
- Department of Neuropathology, Heidelberg University Hospital
- Felix Sahm
- Department of Neuropathology, Heidelberg University Hospital
- Blaise A. Clarke
- Department of Pathology, University Health Network
- Colin J. R. Stewart
- Department of Anatomical Pathology, King Edward Memorial Hospital
- Yemin Wang
- Department of Pathology and Laboratory Medicine, University of British Columbia
- C. Blake Gilks
- Department of Pathology and Laboratory Medicine, University of British Columbia
- Friedrich Kommoss
- Institute of Pathology, Medizin Campus Bodensee
- David G. Huntsman
- Department of Pathology and Laboratory Medicine, University of British Columbia
- Ulrich Schüller
- Institute of Neuropathology, University Medical Center Hamburg-Eppendorf
- Christian Koelsche
- Institute of Pathology, Heidelberg University Hospital
- W. Glenn McCluggage
- Department of Pathology, Belfast Health and Social Care Trust
- Andreas von Deimling
- Department of Neuropathology, Heidelberg University Hospital
- William D. Foulkes
- Department of Human Genetics, McGill University
- DOI
- https://doi.org/10.1038/s41467-023-37092-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
DICER1 syndrome is associated with a predisposition to multiple tumor types. Here, the authors identify and characterize 3 molecular subgroups of mesenchymal tumors with DICER1 mutations.
