Journal of Nepal Medical Association (Dec 2017)

Prevalence of Hepatitis D Among Patients with Hepatitis B Viral Infection Attending a Tertiary Care Centre of Nepal

  • Kiran Regmi,
  • Jeetndra Kaji Shrestha,
  • Sudhamshu KC,
  • Bikash Jaishi,
  • Niyanta Karki,
  • Dipendra Khadka,
  • Sandip Khadka

DOI
https://doi.org/10.31729/jnma.3378
Journal volume & issue
Vol. 56, no. 208

Abstract

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Introduction: Worldwide there is variation in prevalence of Hepatitis D viral infection. Superinfection and co infection with hepatitis B viral infection is known to occur in 15-20 million people. Methods: This was a descriptive cross-sectional hospital based study carried out in NAMS, Bir hospital, Kathmandu, Nepal from period of January 2017 to June 2017. Consecutive patients of chronic hepatitis B viral infection of HBsAg positive with more than two-time upper normal limit of ALT were enrolled and tested for HDV IgG. Results: Forty patients were enrolled during study period. Mean age was 30.9±12.2 years. Males were 28 (70%) and females 12 (30%). Most of the patients were asymptomatic for HBV infection 32 (80%). HBeAg negative chronic hepatitis was most commonly present in 31 (77.5%). Family history of Hepatitis B viral infection was seen in 7 (17.5%) and sexual promiscuity in 5 (12.5%) as the mode of acquisition of hepatitis B viral infection. HBcIgM was positive in three patients with mean HBV DNA of 4.97x105±4.5x105 IU/ml in HBeAg positive group. HDV IgG was negative in all patients. Conclusions: Coinfection and superinfection of hepatitis D virus were found to be uncommon at Bir hospital, Nepal. Keywords: HbsAg; HDV DNA; HDV IgG; Hepatitis B; Hepatitis D.

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