Hippocampal microRNA-26a-3p deficit contributes to neuroinflammation and behavioral disorders via p38 MAPK signaling pathway in rats

Abstract

Highlights 1. MiR-26a-3p is down-regulated in several neurological disease-related model. 2. Knock-down of miR-26a-3p within hippocampus induced behavioral disorders in rats. 3. Knock-down of miR-26a-3p promoted neuroinflammation in hippocampus. 4. Knock-down of miR-26a-3p resulted in dysregulation of synaptic plasticity. 5. MiR-26a-3p regulates neural inflammation and plasticity through the p38/NF-κB pathway.

Keywords

• Neuroinflammation
• Neuroplasticity
• MicroRNA-26a-3p
• p38 MAPK
• Behavioral disorder