Levofloxacin Resistance in Blood and Urine Culture Samples in Khalij Fars Hospital of Bushehr

Abstract

Background: Due to broad spectrum antimicrobial activity of Levofloxacin, it has been used widely around the world. Recently levofloxacin-resistance reports have been published. This study was done to evaluate resistance to levofloxacin in positive urine and blood cultures in Persian Gulf hospital in Bushehr, during 2015-16. Materials and Methods: In  this cross- sectional study all positive urine and blood cultures were enrolled, if the amount of the isolated pathogen  colony counts were more than 105. Culture samples were divided into 3 groups including sensitive, intermediate and resistant; based on bacterial growth around discs. SPSS version 18.0 was used as the statistical analysis program, and a p-value of less than 0.05 was considered statistically significant. Results: Cultures belonged to 150 patients including 61 (%40.7) male and 89 (%59.3) female subjects with mean age of 42.98 ± 29.25 years were studied. Culture samples were consisted of urine (% 50.7) and blood cultures (% 49.3). E.coli was the most common pathogen (% 46) and Klebsiella (% 16.7) was the second pathogen in all cultures. Regarding sensitivity to  levofloxacin, 119 (% 79.3) samples were sensitive, 22 (% 14.7) culture had intermediate sensitivity and 9 (%6) samples were resistant to levofloxacin. The only  resistant pathogen was E.coli. Conclusion: This study showed that Levofloxacin has good activity against many pathogens except for E.coli infections that showed some resistance. However , it can still be a good choice in treatment of most infections.  

Keywords

• Resistance
• levofloxacin
• blood culture
• urine culture