Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer

Marcin Paczkowski; Warren W. Kretzschmar; Bostjan Markelc; Stanley K. Liu; Leoni A. Kunz-Schughart; Adrian L. Harris; Mike Partridge; Helen M. Byrne; Pavitra Kannan

doi:10.1038/s42003-020-01529-5

Communications Biology (Jan 2021)

Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer

Marcin Paczkowski,
Warren W. Kretzschmar,
Bostjan Markelc,
Stanley K. Liu,
Leoni A. Kunz-Schughart,
Adrian L. Harris,
Mike Partridge,
Helen M. Byrne,
Pavitra Kannan

Affiliations

Marcin Paczkowski: Mathematical Institute, University of Oxford
Warren W. Kretzschmar: School of Engineering Sciences in Chemistry Biotechnology and Health, Department of Gene Technology, Science for Life Laboratory, KTH Royal Institute of Technology
Bostjan Markelc: CRUK and MRC Oxford Institute for Radiation Oncology, University of Oxford
Stanley K. Liu: Sunnybrook Research Institute and Departments of Medical Biophysics and Radiation Oncology, University of Toronto
Leoni A. Kunz-Schughart: OncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden and Helmholtz-Zentrum
Adrian L. Harris: CRUK and MRC Oxford Institute for Radiation Oncology, University of Oxford
Mike Partridge: CRUK and MRC Oxford Institute for Radiation Oncology, University of Oxford
Helen M. Byrne: Mathematical Institute, University of Oxford
Pavitra Kannan: CRUK and MRC Oxford Institute for Radiation Oncology, University of Oxford

DOI: https://doi.org/10.1038/s42003-020-01529-5
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Using co-culture experiments and mathematical modelling, Paczkowski et al discover that prostate cancer spheroids comprising mixed tumour cell populations display enhanced growth and reduced radiation sensitivity due to competitive and antagonistic interactions between cell populations. This interdisciplinary approach reveals a role for ecological-type interactions in the radiation response and may be used to study other cancer types.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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