Use of deferoxamine (DFO) in transfusion-dependent β-thalassemia during pregnancy: A retrospective study

Maria Grazia Piccioni; Carmela Capone; Flaminia Vena; Valentina Del Negro; Michele Carlo Schiavi; Valentina D'Ambrosio; Antonella Giancotti; Maria Paola Smacchia; Roberto Brunelli

Taiwanese Journal of Obstetrics & Gynecology (Jan 2020)

Use of deferoxamine (DFO) in transfusion-dependent β-thalassemia during pregnancy: A retrospective study

Maria Grazia Piccioni,
Carmela Capone,
Flaminia Vena,
Valentina Del Negro,
Michele Carlo Schiavi,
Valentina D'Ambrosio,
Antonella Giancotti,
Maria Paola Smacchia,
Roberto Brunelli

Affiliations

Maria Grazia Piccioni: Department of Gynecological and Obstetric Sciences and Urological Sciences, University of Rome “Sapienza”, Umberto I Hospital, V. le del Policlinico 155, 00161 Rome, Italy
Carmela Capone: Department of Gynecological and Obstetric Sciences and Urological Sciences, University of Rome “Sapienza”, Umberto I Hospital, V. le del Policlinico 155, 00161 Rome, Italy; Corresponding author. Department of Gynecological and Obstetric Sciences, and Urological Sciences University of Rome “Sapienza”, Umberto I Hospital. Viale del Policlinico 155, 00161 Rome, Italy.
Flaminia Vena: Department of Gynecological and Obstetric Sciences and Urological Sciences, University of Rome “Sapienza”, Umberto I Hospital, V. le del Policlinico 155, 00161 Rome, Italy
Valentina Del Negro: Department of Gynecological and Obstetric Sciences and Urological Sciences, University of Rome “Sapienza”, Umberto I Hospital, V. le del Policlinico 155, 00161 Rome, Italy
Michele Carlo Schiavi: Department of Gynecological and Obstetric Sciences and Urological Sciences, University of Rome “Sapienza”, Umberto I Hospital, V. le del Policlinico 155, 00161 Rome, Italy
Valentina D'Ambrosio: Department of Gynecological and Obstetric Sciences and Urological Sciences, University of Rome “Sapienza”, Umberto I Hospital, V. le del Policlinico 155, 00161 Rome, Italy
Antonella Giancotti: Department of Gynecological and Obstetric Sciences and Urological Sciences, University of Rome “Sapienza”, Umberto I Hospital, V. le del Policlinico 155, 00161 Rome, Italy
Maria Paola Smacchia: Department of Pediatrics and Child Neuropsychiatry, University of Rome “Sapienza”, Umberto I Hospital, V. le del Policlinico 155, 00161 Rome, Italy
Roberto Brunelli: Department of Gynecological and Obstetric Sciences and Urological Sciences, University of Rome “Sapienza”, Umberto I Hospital, V. le del Policlinico 155, 00161 Rome, Italy

Journal volume & issue: Vol. 59, no. 1
pp. 120 – 122

Abstract

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Objective: To report cases of use of chelation therapy during pregnancy which resulted in favorable outcomes for the babies. Materials and methods: In this retrospective cohort study, we described the evolution and outcome of 9 pregnancies in Italian thalassemic women who received deferoxamine (DFO) inadvertently during early pregnancy. Results: The use of deferoxamine during first trimester did not lead to adverse effects on the fetus or cause major complications for the gestation, although an increase in iron burden was observed after suspending chelation therapy. Conclusion: In our experience, iron-chelation therapy might be administrated in pregnancy where the benefits to the mother outweigh the potential risks to the baby. Keywords: Deferoxamine, Iron chelation therapy, Magnetic resonance T2*, Pregnancy, Thalassemia

Published in Taiwanese Journal of Obstetrics & Gynecology

ISSN: 1028-4559 (Print)
Publisher: Elsevier
Country of publisher: Taiwan, Province of China
LCC subjects: Medicine: Gynecology and obstetrics
Website: http://www.journals.elsevier.com/taiwanese-journal-of-obstetrics-and-gynecology/

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