Nature Communications (Feb 2019)

Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase

  • Carola E. H. Rosenkilde,
  • Christian Munck,
  • Andreas Porse,
  • Marius Linkevicius,
  • Dan I. Andersson,
  • Morten O. A. Sommer

DOI
https://doi.org/10.1038/s41467-019-08529-y
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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Development of bacterial resistance to an antibiotic can lead to collateral sensitivity to another drug. Here, the authors study collateral sensitivity conferred by mutations in the horizontally acquired β-lactamase CTX-M-15, and identify antibiotic combinations that constrain the evolution of resistance.