Defluorosilylation of fluoroarenes and fluoroalkanes

Benqiang Cui; Shichong Jia; Etsuko Tokunaga; Norio Shibata

doi:10.1038/s41467-018-06830-w

Nature Communications (Oct 2018)

Defluorosilylation of fluoroarenes and fluoroalkanes

Benqiang Cui,
Shichong Jia,
Etsuko Tokunaga,
Norio Shibata

Affiliations

Benqiang Cui: Department of Nanopharmaceutical Sciences and Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso
Shichong Jia: Department of Nanopharmaceutical Sciences and Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso
Etsuko Tokunaga: Department of Nanopharmaceutical Sciences and Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso
Norio Shibata: Department of Nanopharmaceutical Sciences and Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso

DOI: https://doi.org/10.1038/s41467-018-06830-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

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Transformation of strong C-F bonds into C-Si bonds is an extremely useful strategy for further derivatization of organic molecules. Here, the authors report a nickel-catalyzed strategy to convert aryl fluorides into sylylated arenes while defluorosilylation of alkyl fluorides is achieved under metal-free conditions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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