A human multi-lineage hepatic organoid model for liver fibrosis

Yuan Guan; Annika Enejder; Meiyue Wang; Zhuoqing Fang; Lu Cui; Shih-Yu Chen; Jingxiao Wang; Yalun Tan; Manhong Wu; Xinyu Chen; Patrik K. Johansson; Issra Osman; Koshi Kunimoto; Pierre Russo; Sarah C. Heilshorn; Gary Peltz

doi:10.1038/s41467-021-26410-9

Nature Communications (Oct 2021)

A human multi-lineage hepatic organoid model for liver fibrosis

Yuan Guan,
Annika Enejder,
Meiyue Wang,
Zhuoqing Fang,
Lu Cui,
Shih-Yu Chen,
Jingxiao Wang,
Yalun Tan,
Manhong Wu,
Xinyu Chen,
Patrik K. Johansson,
Issra Osman,
Koshi Kunimoto,
Pierre Russo,
Sarah C. Heilshorn,
Gary Peltz

Affiliations

Yuan Guan: Department of Anesthesiology, Pain and Perioperative Medicine
Annika Enejder: Department of Materials Science and Engineering, Stanford University
Meiyue Wang: Department of Anesthesiology, Pain and Perioperative Medicine
Zhuoqing Fang: Department of Anesthesiology, Pain and Perioperative Medicine
Lu Cui: Department of Pathology, Institute of Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of Medicine
Shih-Yu Chen: Shih-Yu Chen, Institute of Biomedical Sciences, Academia Sinica
Jingxiao Wang: Department of Anesthesiology, Pain and Perioperative Medicine
Yalun Tan: Department of Anesthesiology, Pain and Perioperative Medicine
Manhong Wu: Department of Anesthesiology, Pain and Perioperative Medicine
Xinyu Chen: Department of Anesthesiology, Pain and Perioperative Medicine
Patrik K. Johansson: Department of Materials Science and Engineering, Stanford University
Issra Osman: Department of Anesthesiology, Pain and Perioperative Medicine
Koshi Kunimoto: Department of Pathology, Institute of Stem Cell Biology and Regenerative Medicine (ISCBRM), Stanford University School of Medicine
Pierre Russo: Perelman School of Medicine at The University of Pennsylvania
Sarah C. Heilshorn: Department of Materials Science and Engineering, Stanford University
Gary Peltz: Department of Anesthesiology, Pain and Perioperative Medicine

DOI: https://doi.org/10.1038/s41467-021-26410-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Autosomal recessive polycystic kidney disease (ARPKD) is a genetic disorder which is associated with kidney and liver pathology, including liver fibrosis. Here the authors develop and characterize human liver organoids with a ARPKD mutation, and find that they show aspects of the pathology, including fibrosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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